Database : HANSEN Search on : ANTIINFLAMATORIOS ESTEROIDES [Subject descriptor] References found : 6 [refine] Displaying: 1 .. 6   in format [Detailed]

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Id: 13937 Author: Teles, Rosane M. B; Moraes, Milton O; Geraldo, Natasha T. R; Salles, Ana M; Sarno, Euzenir N; Sampaio, Elizabeth P Title: Differential TNFalpha mRNA regulation detected in the epidermis of leprosy patients ..- Source: s.l; s.n; 2002. 8 p. ilus, tab, graf. Abstract: The epidermis is an important site of the immunoinflammatory response in the skin. In the present study, the expression of cytokine and ICAM-1 (intercellular adhesion molecule-1) genes was evaluated by RT-PCR in the epidermis isolated from biopsies from 25 reactional leprosy patients. TNFalpha and IL-6 mRNAs were detected in all individuals during the reactional state (reversal reaction or erythema nodosum leprosum), IL-8 message was detected in 66.6 per cent and 62.5 per cent of the patients, IL-12 mRNA was present in 91.6 per cent and 62.5 per cent and ICAM-1 in 100 per cent and 71.4 per cent, respectively. In addition, when skin biopsies were obtained from the same patients before and during the reactional episode, an enhancement in cytokine mRNA, but not in ICAM-1 mRNA, was observed. Seven patients were also evaluated at the onset of reaction and during antiinflammatory treatment. In contrast to a preferential decrease in the TNFalpha gene detected in the dermis, during the treatment phase, persistent/enhanced TNFalpha mRNA expression was detected in the epidermis in six out of the seven patients assessed. This peculiar pattern of expression might reflect a differential impact that in vivo antiinflammatory therapy has on the epidermis. The present findings indicate that the epidermis plays an important role in the local inflammatory response in leprosy and that the profile of response detected in the epidermis during the reactions may be regulated differently from that in the dermis. (AU). Descriptors: CITOCINAS/genet CITOCINAS/metab ANTIINFLAMATORIOS ESTERÓIDES/uso terap DERME/metab HANSENOSTATICOS/uso terap EPIDERME/metab MOLECULA 1 DE ADESAO INTERCELULAR/genet MOLECULA 1 DE ADESAO INTERCELULAR/metab HANSENIASE/quimioter HANSENIASE/metab PENTOXIFILINA/uso terap ANTIINFLAMATORIOS/uso terap RNA MENSAGEIRO/metab TALIDOMIDA/uso terap PREDNISONA/uso terap FATOR DE NECROSE TUMORAL/genet FATOR DE NECROSE TUMORAL/metab Limits: HUMANO MASCULINO FEMININO ADULTO MEIA-IDADE IDOSO SUPPORT, NON-U.S. GOV'T Electronic Medium: http://www.ilsl.br Location: BR191.1; 09157/s

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Id: 12254 Author: Bourée, P; Brette, A. de; Carsalade, G. Y. de Title: Réaction lépreuse tardive apparue 18 mois après la fin d'un traitement Late reversal leprous reaction appearing 18 months after the termination of treatment- Source: s.l; s.n; mars 2001. 1 p. . Descriptors: ANTIINFLAMATORIOS NAO ESTEROIDES ANTIINFLAMATORIOS NAO ESTEROIDES ANTIINFLAMATORIOS ESTEROIDES ANTIINFLAMATORIOS ESTEROIDES BIOPSIA CLOFAZIMINA CLOFAZIMINA TINTURAS SEGUIMENTOS HIPERSENSIBILIDADE TARDIA LEPROSTATICOS LEPROSTATICOS LEPROSTATICOS HANSENIASE DIMORFA HANSENIASE DIMORFA HANSENIASE DIMORFA MYCOBACTERIUM LEPRAE MYCOBACTERIUM LEPRAE PREDNISONA PREDNISONA PELE FATORES DE TEMPO Limits: RELATO DE CASO Location: BR191.1; 08684/s

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Id: 11439 Author: Bourée, P; Brette, A. de; Carsalade, G. Y. de Title: Réaction lépreuse tardive apparue 18 mois après la fin d'un traitement Late reveral leprous reaction appearing 18 months after the termination of treatment- Source: s.l; s.n; 2001. 1 p. . Descriptors: ANTIINFLAMATORIOS NAO ESTEROIDES ANTIINFLAMATORIOS NAO ESTEROIDES ANTIINFLAMATORIOS ESTEROIDES ANTIINFLAMATORIOS ESTEROIDES BIOPSIA CLOFAZIMINA CLOFAZIMINA TINTURAS SEGUIMENTOS HIPERSENSIBILIDADE TARDIA LEPROSTATICOS LEPROSTATICOS LEPROSTATICOS HANSENIASE DIMORFA HANSENIASE DIMORFA HANSENIASE DIMORFA MYCOBACTERIUM LEPRAE MYCOBACTERIUM LEPRAE PREDNISONA PREDNISONA PELE FATORES DE TEMPO Limits: RELATO DE CASO Location: BR191.1; 08321/s

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Id: 11024 Author: Zoprbas, P; Kontochristopoulos, G; Detsi, I; Apostolakis, E; Kouris, N; Katsambas, A Title: Borderline tuberculoid leprosy coexisting with systemic lupus erythematosus ..- Source: s.l; s.n; may 1999. 2 p. . Descriptors: AGENTES ANTIINFECCIOSOS DE FLUOROQUINOLONA ANTIINFLAMATORIOS ESTEROIDES CIPROFLOXACINA ULCERA DO PÉ ULCERA DO PÉ HANSENIASE DIMORFA HANSENIASE DIMORFA HANSENIASE DIMORFA LUPUS ERITEMATOSO SISTEMICO LUPUS ERITEMATOSO SISTEMICO LUPUS ERITEMATOSO SISTEMICO PREDNISOLONA Limits: RELATO DE CASO Location: BR191.1; 07489/s

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Id: 10366 Author: Chogle, Arun; Nagral, Aabha; Soni, Abhay; Agale, Sachin; Jamadar, Zakir Title: Dapsone hypersensitivity syndrome with coexisting acute hepatitis E ..- Source: s.l; s.n; 2000. 2 p. . Descriptors: DOENÇA AGUDA ADOLESCENCIA ANTIINFLAMATORIOS ESTEROIDES DAPSONA DAPSONA HIPERSENSIBILIDADE A DROGAS HEPATITE E LEPROSTATICOS LEPROSTATICOS HANSENIASE HANSENIASE PREDNISOLONA SINDROME Limits: RELATO DE CASO Location: BR191.1; 07498/s

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Id: 10247 Author: Fegan, David; Glennon, Jacqueline Title: Use of steroids in dermatological emergencies ..- Source: s.l; s.n; 1993. 3 p. ilus. Descriptors: ANTIINFLAMATORIOS ESTEROIDES ANTITUBERCULOSOS DAPSONA SERVIÇOS MÉDICOS DE EMERGENCIA ERITEMA MULTIFORME ERITEMA MULTIFORME HANSENIASE DIMORFA PENFIGO PREDNISOLONA DERMATOPATIAS Location: BR191.1; 06957/s

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